GLP-1 Nausea and Vomiting: What the Labels Say and When to Call

Short answer: Nausea is the most common side effect on GLP-1 labels. In weight-reduction trials it was reported by 44% of Wegovy® (semaglutide) patients and 25% to 29% of Zepbound® (tirzepatide) patients, against 16% and 8% on placebo. The Zepbound label says most nausea, vomiting and diarrhea events happened while the amount of medicine was being stepped up, and decreased over time. This page reports what the labels say. It does not give treatment advice.

How often did nausea and vomiting happen in trials?

These are each label’s own figures from placebo-controlled trials, as listed on DailyMed on October 30, 2026. Different trials had different designs and different people, so they cannot be lined up against each other. The first three rows are weight-reduction trials; the last two are trials in adults with type 2 diabetes.

Label	Nausea: placebo	Nausea: treated	Vomiting: placebo	Vomiting: treated
Wegovy injection (2.4 mg)	16%	44%	6%	24%
Zepbound (three strengths studied)	8%	25%, 29%, 28%	2%	8%, 11%, 13%
Foundayo (three strengths studied)	10%	26%, 34%, 35%	4%	13%, 21%, 24%
Ozempic (two strengths studied)	6.1%	15.8%, 20.3%	2.3%	5%, 9.2%
Mounjaro (three strengths studied)	4%	12%, 15%, 18%	2%	5%, 5%, 9%

Treated figures are listed from the lowest strength studied to the highest. Your prescriber chooses what fits you.

When do nausea and vomiting tend to happen?

The Zepbound label says “the majority of nausea, vomiting, and/or diarrhea events occurred during dose escalation and decreased over time.” The Ozempic label says “the majority of reports of nausea, vomiting, and/or diarrhea occurred during dose escalation.” How your own dose is stepped up is for your prescriber to decide, and this page does not cover it.

What do the labels say about dehydration?

The labels connect stomach and bowel reactions to a more serious problem. Both the Wegovy and Zepbound labels say most reported cases of acute kidney injury were in patients with reactions “leading to dehydration such as nausea, vomiting, or diarrhea.” The Medication Guides tell people to contact their healthcare provider right away about nausea, vomiting or diarrhea “that does not go away.” See GLP-1 constipation and diarrhea for the related label figures.

What other causes does MedlinePlus list?

MedlinePlus, the NIH patient-information site, says nausea and vomiting “can be symptoms of many different conditions,” including infections, migraines, motion sickness, food poisoning, reflux, ulcers, intestinal obstruction and “medicines, including those for cancer chemotherapy.” That is why persistent symptoms deserve a conversation with a clinician instead of an assumption.

How can you track how you feel?

A note with the date of each shot and when nausea started and stopped shows your provider the pattern over time. Weeko, a shot tracker coming to iPhone and Android, is being built around that kind of simple log. It is a logbook, not medical guidance.

For the complete list of label side effects, see GLP-1 side effects: a plain-language guide. For tiredness, see GLP-1 fatigue.

When to call your doctor

MedlinePlus says to contact your health care provider immediately if you have:

• Vomiting that lasts longer than 24 hours
• Blood in the vomit
• Severe abdominal pain
• Severe headache and stiff neck
• Signs of dehydration, such as dry mouth, infrequent urination or dark urine

Also call about nausea, vomiting or diarrhea that does not go away while you use a GLP-1 medicine, and ask your prescriber before changing or stopping it.